EC50 of Remifentanil to Prevent Propofol Injection Pain
홍훈표, 고현민, 윤지영, 윤지욱, 박훈효, 노영채,
소속 상세정보
홍훈표 ( Hong Hun-Pyo ) - 부산대학교 치의학전문대학원 치과마취통증학교실
고현민 ( Ko Hyun-Min ) - 부산대학교 치의학전문대학원 치과마취통증학교실
윤지영 ( Yoon Ji-Young ) - 부산대학교 치의학전문대학원 치과마취통증학교실
윤지욱 ( Yoon Ji-Uk ) - 부산대학교 의학전문대학원 마취통증의학교실
박훈효 ( Park Hun-Hyo ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
노영채 ( Roh Young-Chea ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
KMID : 0980220130130030089
Abstract
Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50).
Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra®; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of 3 μg/ml.
Results: The EC50 of remifentanil to prevent the propofol injection pain was 1.80 ± 0.35 ng/ml by Dixon’s up and down method.
Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was 1.80 ± 0.35 ng/ml for propofol TCI anesthesia.
키워드
Injection; Pain; Propofol; Remifentanil
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